Adapaleno [INN-Spanish]

Adapaleno [INN-Spanish] Brand names, Adapaleno [INN-Spanish] Analogs

Adapaleno [INN-Spanish] Brand Names Mixture

No information avaliable

Adapaleno [INN-Spanish] Chemical_Formula

C₂₈H₂₈O₃

Adapaleno [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic3/adapalene.htm

Adapaleno [INN-Spanish] fda sheet

Adapaleno_[INN-Spanish] FDA

Adapaleno [INN-Spanish] msds (material safety sheet)

Adapaleno_[INN-Spanish] MSDS

Adapaleno [INN-Spanish] Synthesis Reference

No information avaliable

Adapaleno [INN-Spanish] Molecular Weight

412.52 g/mol

Adapaleno [INN-Spanish] Melting Point

No information avaliable

Adapaleno [INN-Spanish] H₂O Solubility

Practically Insoluble

Adapaleno [INN-Spanish] State

Solid

Adapaleno [INN-Spanish] LogP

7.884

Adapaleno [INN-Spanish] Dosage Forms

Gel (0.1%); Solution; Pledglets; Cream

Adapaleno [INN-Spanish] Indication

For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.

Adapaleno [INN-Spanish] Pharmacology

Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.

Adapaleno [INN-Spanish] Absorption

Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials

Adapaleno [INN-Spanish] side effects and Toxicity

The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.

Adapaleno [INN-Spanish] Patient Information

Adapaleno [INN-Spanish] Organisms Affected

Humans and other mammals